Polypropylene glycol 2000

Polypropylene glycol 2000 - Names and Identifiers

Name	Poly propylene glycol
Synonyms	PPG poly(oxypropylene) poly(propene oxide) Poly propylene glycol Poly(propylene glycol) POLYPROPYLENE GLYCOL 400 POLYPROPYLENE GLYCOL 700 POLYPROPYLENE GLYCOL 2000 POLYPROPYLENE GLYCOL 1000 Polypropylene glycol diol Polypropylene glycol 2000 POLYPROPYLENE GLYCOL P 400 Poly(propylene glycol) 4000 Poly(propylene glycol) 3000 Poly(propylene glycol) 1000 Polypropylene glycol - 2000 grade polypropylene glycol standard 5300 POLYPROPYLENE GLYCOL, DIOL TYPE, 700 POLYPROPYLENE GLYCOL, DIOL TYPE, 1000 POLYPROPYLENE GLYCOL, DIOL TYPE, 2,000 (2S)-2-{[(2R)-2-hydroxypropyl]oxy}propan-1-ol (2R)-2-{[(2R)-2-hydroxypropyl]oxy}propan-1-ol (2R)-2-{[(2S)-2-hydroxypropyl]oxy}propan-1-ol (2S)-2-{[(2S)-2-hydroxypropyl]oxy}propan-1-ol
CAS	25322-69-4
EINECS	200-338-0
InChI	InChI=1/C6H14O3/c1-5(8)4-9-6(2)3-7/h5-8H,3-4H2,1-2H3/t5-,6+/m0/s1

Polypropylene glycol 2000 - Physico-chemical Properties

Molecular Formula	CH4
Molar Mass	16.04246
Density	1.01g/mLat 20°C
Melting Point	-40 °C
Boling Point	>300 °C
Flash Point	230 °C
Water Solubility	PRACTICALLY INSOLUBLE
Solubility	Insoluble in water.
Vapor Presure	<0.01 mm Hg ( 20 °C)
Vapor Density	>1 (vs air)
Appearance	Transparent liquid
Specific Gravity	1.005
Color	White to light gray
Storage Condition	Room Temprature
Stability	Stable. Substances to be avoided include strong oxidizing agents.
Refractive Index	n20/D 1.451
MDL	MFCD00084446
Physical and Chemical Properties	A colorless to yellowish viscous liquid.
Use	For Defoamers

Polypropylene glycol 2000 - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	1
RTECS	TR5250000
TSCA	Yes
HS Code	39072090

Polypropylene glycol 2000 - Upstream Downstream Industry

Raw Materials

Propylene oxide

Polypropylene glycol 2000 - Reference

Reference

1. Liu Changjian, Liu Hongli, Han Xue, Li Yajing, Li Hongyan, Li Jing. Preparation and Properties of Eloshite Modified Polyether Sealant [J]. New chemical materials, 2021,49(03):252-255 260.
2. [IF = 5.582] Tu Jing et al."Highly stretchable, high efficiency room temperature self-healing polyurethane adhesive based on hydrogen bonds - applicable to solid rocket propellants." Polym Chem-Uk. 2021 Aug;12(31):4532-4545
3. [IF = 6.4] Lanju Wang et al."Development of a Point-of-Care Test Based on Selenium Nanoparticles for Heart-Type Fatty Acid-Binding Proteins in Human Plasma and Blood." Int J Nanomed. 2022; 17: 1273-1284

Polypropylene glycol 2000 - Reference Information

LogP	0.01 at 25℃
NIST chemical information	Information provided by: webbook.nist.gov (external link)
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
introduction	polypropylene glycol is a polymer with the molecular formula H(C3H6O)nOH, a colorless to light yellow viscous liquid. Not volatile. Non-corrosive. The molecular weight of general commodities is 400~2050. Lower molecular weight polymers are soluble in water. Higher molecular weight polymers are only slightly soluble in water, soluble in oils, many hydrocarbons, aliphatic alcohols, ketones, esters, etc. The hydroxyl groups at both ends of the molecule can be esterified to form monoesters or diesters. Its monoester is a non-ionic surfactant, and can also react with alcohol to form ether. It is a solvent for vegetable oil, resin and paraffin, and is also used to prepare alkyd resin, emulsifier, demulsifier, lubricating oil and plasticizer. It is obtained by condensation of propylene oxide and propylene glycol under high pressure or in the presence of an acidic catalyst.
use limit	for fermentation process, limited to GMP (GB 2760-96).
toxicity	LD50>10 g/kg (mouse, oral). mutagenicity test, Ames test, mouse bone marrow micronucleus test, mouse sperm aberration test, no abnormalities. Propylene glycol stimulation of rabbit corneal epithelium will produce temporary slight corneal congestion. If propylene glycol is washed with 50% aqueous solution for 5 minutes to remove propylene glycol, it will not cause any harm, but if it is stimulated with undiluted propylene glycol for 5 minutes, it will produce moderate reaction.
emergency operation	treatment method after contact: 1. inhalation: move to fresh air and rest. 2. Skin contact: remove contaminated clothes and rinse skin or shower with plenty of water. 3. eye contact: open your eyes, rinse with flowing water for 10 minutes, and then see a doctor.
use	defoamer; Solvents for vegetable oil, wax and resin. Used for eucalyptus sugar, beverages, candy, yeast, etc. Defoamer. Used in the production of yeast, monosodium glutamate, etc. The defoaming efficiency is several to dozens of times that of edible oil.
production method	glycerin and refined propylene oxide are polymerized under the catalysis of potassium hydroxide at a temperature of 90~95 ℃ and a pressure of 0.4 ~ 0.5MPa. Then cool to 60~70 ℃, press the material into a neutralization kettle, add water under stirring to neutralize excess potassium hydroxide, then add phosphoric acid at 60~70 ℃ to neutralize to pH 6~7, then slowly raise the temperature to 110~120 ℃, dehydrate and filter in vacuum. It is formed by the addition reaction of propylene glycol polymer and water.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)